PHASE II TRIAL OF AKT INHIBITOR MK-2206 IN PATIENTS WITH ADVANCED BREAST CANCER WHO HAVE TUMORS WITH PIK3CA OR AKT MUTATIONS, AND/OR PTEN LOSS/PTEN MUTATION

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was objective response r

Abstract Background Latest evidence suggests that periodontitis is prevalent among patients with chronic obstructive pulmonary disease (COPD), while recent studies have also reported a potential benefit of periodontal treatment on several COPD outcomes.This systematic review aims to determine the impact of periodontal treatment on exacerbation rate

ABSTRACTAssessments in agricultural crops indicate that alterations in the landscape adjacent to the crops can result in reduced productivity due to loss or low abundance of pollinating agents.In the canola crop, production is partially Fridge Roller Base dependent on insect pollination.Therefore, knowledge of the faunal diversity within and near c

The implementation of direct regional head elections has been going on for two decades.The problem so far is the dispute resolution institution, until now the regional head Buttons/Pins election dispute settlement in Indonesia is still divided into several institutions such as the General Election Supervisory Board, the State Administrative Court,